FFPE Tissue Microarrays (TMAs) & Cells: DNA/RNA Extraction for Cancer Research

Cambrian Bioworks offers dedicated kits for both RNA and genomic DNA (gDNA) extraction from FFPE tissue. The FFPE RNA Isolation Kit delivers high-integrity RNA with DV200 >70%, while the FFPE gDNA Isolation Kit provides high-molecular-weight DNA suitable for NGS, PCR, and oncology mutation analysis.

Both kits complete the extraction workflow in just 28 minutes after the lysis step. No overnight incubation is required, enabling same-day processing. This significantly reduces turnaround time in oncology, diagnostics, and high-throughput research settings compared to conventional FFPE extraction methods.

Yes. Both the FFPE RNA and gDNA kits are designed for use with the Manta automated nucleic acid extraction platform from Cambrian Bioworks. The gDNA kit supports 1 to 32 samples per run, and the RNA kit is compatible with 96-well format systems, enabling scalable high-throughput workflows.

Extracted DNA and RNA from Cambrian Bioworks FFPE kits are suitable for a wide range of applications including Next-Generation Sequencing (NGS), PCR-based mutation analysis, gene expression profiling, RNA-seq, fusion gene detection, biomarker discovery, tumor subtype classification, immune profiling, and retrospective clinical research.

The Cambrian FFPE RNA Isolation Kit requires as few as four 10 µm FFPE tissue curls as input material. This low input requirement is especially important in oncology settings where biopsy samples and archival FFPE blocks are often limited or precious, minimizing sample waste while maximizing nucleic acid yield.

The FFPE RNA Isolation Kit is designated as Research Use Only (RUO). The FFPE gDNA Isolation Kit is intended for both research and clinical diagnostic laboratory settings and holds CE-IVD and CDSCO IVD certifications. For clinical implementation, regulatory status should be confirmed directly with Cambrian Bioworks based on your specific jurisdiction and application.