FFPE DNA Extraction Kits: Automated Methods for Formalin-Fixed Tissue

After the lysis step, the automated extraction workflow on the Manta system completes in just 28 minutes. The pre-filled cartridge design eliminates manual pipetting steps, allowing lab personnel to load the lysate and let the instrument handle the rest, significantly reducing hands-on time and operator variability.

The high-molecular-weight gDNA isolated by this kit is validated for use in Next-Generation Sequencing (NGS), PCR-based mutation analysis, oncology studies including tumor content analysis, reproductive genetics, infectious disease testing, and translational research. The quality and integrity of output DNA supports both research and clinical diagnostic workflows.

The Cambrian FFPE gDNA Isolation Kit supports flexible throughput from 1 to 32 samples per single Manta run. Crucially, it can process each sample individually without wasting reagents on unused positions, making it ideal for oncology labs where precious FFPE samples must be conserved.

Yes. The kit is backed by Cambrian Bioworks' CE-IVD mark under EU Regulation 2017/746 (IVDR) and CDSCO IVD certification, making it suitable for use in clinical diagnostic laboratory settings. The company also holds ISO 13485 certification for quality management in medical device manufacturing.

The Cambrian FFPE gDNA Isolation Kit (Cat. No. CBWM100.64I) contains reagents for 64 reactions on the Manta automated extraction system. Pricing is available on request. You can contact Cambrian Bioworks through their website at cambrianbioworks.com/contact_us or reach the team at connect@cambrianbioworks.com to place an order or request a demo.

Older FFPE blocks may exhibit increased DNA degradation and crosslinking due to prolonged formalin fixation, which can reduce yield and fragment size. Cambrian Bioworks provides FAQ guidance specifically addressing FFPE block age effects, decrosslinking optimization, paraffin wax removal, and wax contamination to help labs achieve consistent results even with aged archival tissue.