Blood DNA Purification: Maxwell 16 Alternatives & Automated Options

DNA purification kits use magnetic bead-based technology to selectively bind nucleic acids from lysed samples. The Cambrian Whole Blood gDNA Isolation Kit, for example, lyses blood cells, binds DNA to magnetic beads within pre-filled cartridges, washes away contaminants, and elutes purified DNA — all automated on the Manta instrument in under 30 minutes, delivering A260/280 ratios of 1.8–2.0.

gDNA extraction isolates genomic DNA from white blood cells in whole blood, producing high molecular weight DNA suitable for NGS, PCR, and microarrays. cfDNA extraction targets short, cell-free DNA fragments (150–200 bp) circulating in plasma, primarily used for liquid biopsy, ctDNA detection, and MRD monitoring in oncology research workflows.

The Cambrian Whole Blood gDNA Isolation Kit supports flexible throughput of 1 to 32 samples per run on the Manta instrument, with a 28-minute on-deck processing time. This eliminates the need to batch samples and allows labs to process even single samples efficiently without wasting reagents or consumables.

Yes. The Cambrian Whole Blood gDNA Isolation Kit delivers DNA with A260/280 ratios of 1.8–2.0, compatible with NGS, PCR, microarrays, and genetic testing. The OncoSeek cfDNA Extraction Kit is optimized for NGS library preparation, qPCR, and digital PCR (ddPCR) workflows used in liquid biopsy and oncology research.

The OncoSeek cfDNA Extraction Kit requires only 1 mL of plasma input — half the volume needed by leading competitors — while delivering 5–20× higher cfDNA yield. This is especially advantageous for precious or limited clinical samples, enabling more analyses from each patient draw while maintaining minimal genomic DNA contamination.

The OncoSeek cfDNA Extraction Kit is currently designated For Research Use Only (RUO) and is intended for oncology research and liquid biopsy applications. However, Cambrian Bioworks holds ISO 13485 certification, CE-IVD mark, and CDSCO IVD certification for its product manufacturing quality management framework. Contact Cambrian Bioworks for the latest regulatory status updates.